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In a review of studies, researchers found that while vitamin B12 supplementation did not improve depressive symptoms, low vitamin B12 levels were linked to an increased risk of developing depression

Copper peptide (GHK-Cu) works through an entirely different mechanism, and the distinction matters more than most comparison articles will tell you

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This is because aging adults often develop problems with the acids and stomach enzymes needed to process the vitamin

Curiously, the strongest anxiolytic effect came from the smallest administered dose of 0.5 mcg/kg body weight, whereas larger doses had smaller effects on anxiety [12]