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Conversely, GluN2A-containing NMDA receptors can activate pro-survival signaling pathways, including ERK and CREB phosphorylation, and enhance BDNF (Chen et al
doi: 10.1111/aos.12784

Common side effects include mild pain at the injection site, dizziness, or nausea
20,38,39 Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNA regulation, also play a critical role in regulating gene activity and impacting MTX metabolism and toxicity

IqbalBGhildiyalASinghSSiddiquiSKumariPArshadMet al

Contraindication: Preserved bacteriostatic preparations must not be used for neonates or newborns, as benzyl alcohol toxicity has been associated with severe neurological and metabolic complications in infants