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The monomer also impairs retinal pigment epithelium functionality by elevating paracellular permeability and disrupting the tight junction proteins ZO-1 and occludin, while another study found that mCRP upregulates IL-8 and CCL2 gene expression and protein secretion, and also binds to complement factor H, which dampens its proinflammatory activity in these cells while increasing phagocytosis [110,111]

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However, some tissues, such as the liver, spleen, and tumors, feature endothelial fenestrations that aid in delivering genes to cells outside the bloodstream

2018;24:97108.e4

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