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Ferroptosis: past, present and future

The clinical data in this regard is still very limited and needs expanding through randomized, placebo-controlled studies to draw final conclusions on whether polyphenols may be a class of clinically effective nutraceuticals in patients with CFS

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Enhanced choline uptake and metabolism, and increased serum choline are hallmarks of many cancers and correlate with a higher risk of overall cancer with a poor prognosis (203, 204)

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Ketogenesis is mainly modulated by insulin but also by other hormones like glucagon, cortisol, thyroid hormones, and catecholamines, which can increase free fatty acids availability for the ketogenic pathway [21,22]