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During healthy states, the balance between these positive and negative actions of the BMAd secretome likely helps to maintain space within the skeleton for both BMAds and hematopoiesis, while avoiding any pathologic destruction or destabilization of the skeletal niche

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[DOI] [PubMed] [Google Scholar] Bonomini M., Zammit V., Pusey C.D., De Vecchi A., Arduini A

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However, more research is needed to investigate the effect of the various available treatments on prognosis
