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8,9 Low-level laser therapy (LLLT) is a safe, simple, and non-invasive treatment approach that has been considered an adjuvant therapy for various diseases including multiple sclerosis, autoimmune thyroiditis, join disorders, wound healing, Alzheimers disease, and also RA due to its photobiomodulating effects, pain reduction and direct interference with inflammatory responses

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480,481 Together, these findings underscore the central role of the LPA-LPAR axis in orchestrating chemoresistance and radioresistance through multifaceted mechanisms involving prosurvival signaling, metabolic adaptation, and DNA repair, identifying an actionable target to increase therapeutic efficacy