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Glucagon receptors are highly concentrated not only in the liver, which is the preferred site for T3 action, but also in adipose tissues, kidney, and the cardiovascular system resulting in metabolic enhancement along with toxicity risk

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A minimally clinically significant difference has not been established for sarcoidosis patients with painful neuropathy, but for patients with cardiopulmonary disease, the minimally clinically significant difference was determined to be a low as 25 m (42)

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