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These alterations are the probable result of the lengthy cellular damage induced by MTX resulting in increased levels of ROS leading to DNA injury, oxidation, and proliferation inhibition

Cardioprotective effect of modified peroxiredoxins in retrograde perfusion of isolated rat heart under conditions of oxidative stress

Antimicrob Agents Chemother 57:382389

However, translational challenges persist, including the lack of pharmacokinetic standardization between oral and intravenous routes, tumor-type-specific response heterogeneity, and incomplete understanding of VCs immunomodulatory dynamics

The glutamate can be transferred to glutamatergic neurons or to GABAergic neurons where, in the latter cells, the glutamate serves as a substrate for GABA synthesis

10.1021/acsnano.9b00300 60 WangB.DaiY.KongY.DuW.NiH.ZhaoH.et al (2020)