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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

More recently, niraparib demonstrated a significant extension of progression-free survival in patients with ovarian cancer, leading to FDA approval for the treatment of recurrent platinum-sensitive ovarian cancer (Kim et al., 2015)

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ABSTRACT Free radicals are common outcome o f no rmal aerob ic cellu la r metabolism

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