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These two metabolites share a 3-hydroxy-( Z )-pentenyl- cis -epoxide moiety that was identified as the pharmacophore involved in nociceptor sensitization mediation

580,581 Catecholamines, synthesized from the amino acid precursors phenylalanine and tyrosine, are a class of neurological substances

Loss in body weight Obesity is recognized as an independent risk factor for DKD [78]

DAF-16 was reported to translocate into the nucleus and activate the cyp-35B promoter in response to BA exposure 26

Therefore, the above-mentioned compounds may exert therapeutic effects on DN by inhibiting ferroptosis in renal tubular cells

Therefore, the above-mentioned antidiabetic medications will lead to a disbalance in the GH/insulin ratio, meaning a low GH and a high insulin level