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In this article, we explore the significance of healthy volunteers in clinical trials and their impact on drug development

A study using a panel of cell lines of high-risk neuroblastoma, a cancer characterized by increased MAPK signaling, found drastic variations in sensitivity to serine/tyrosine/threonine kinase inhibitors between these cell lines ( via IGF-1R reactivated MAPK signaling to mediate cancer cell drug resistance, highlighting the concomitant targeting of MEK and IGF-1R/MAPK signaling pathways as a potential therapeutic strategy in high-risk neuroblastoma

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Cipriano, A

Preprint at bioRxiv , (2021)