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Vitamin B12 deficiency has been associated with depression in adults, children and the elderly [5-16]

Potential interactions include: Metformin (used for type 2 diabetes) Proton pump inhibitors (PPIs) and H2-receptor antagonists (used for acid reflux) Colchicine (used for gout) Nitrous oxide (anaesthetic gas that can inactivate B12) Chloramphenicol (may reduce the haematological response to B12 therapy) If you take any of these medications long-term, discuss B12 monitoring with your healthcare provider

doi: 10.1038/s41430-023-01360-1

If you take B12 supplements, multivitamins, or receive B12 injections, the high result is almost always a reflection of your intake and is clinically insignificant

This prohibition extends to penta deca peptide arginate, as the active sequence is identical

"Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme." Trends in Endocrinology & Metabolism