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Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial

Romeiro C

Both compounds require subcutaneous administration for bioavailabilityoral forms degrade rapidly in gastric acid and hepatic first-pass metabolism

first trimester to assess viability

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encapsulated entacapone into PEGylated PLGA (PEG-PLGA@Ent) nanoparticles and nanostructured lipid carriers (NLCs) to enhance its bioavailability and pharmacological efficacy while mitigating its limitations, such as low oral bioavailability and rapid clearance 130