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5b), a component of the HOPS complex

Proton pump inhibitors: These drugs reduce stomach acid, which is necessary for B12 release from food

Metabolic disorders, such as hyperglycemia and hyperlipidemia, can damage renal cells through oxidative stress-mediated injury, inflammatory response, apoptosis, and autophagy, leading to renal tubulointerstitial inflammation and fibrosis, glomerular hypertrophy, glomerulosclerosis and ultimately renal insufficiency [2]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Vuolo L., Di Somma C., Faggiano A., Colao A

Based on in vitro study, the treatment of 1 mg/mL GSH significantly inhibited melanin production and tyrosinase activity
