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Incomplete resections (R1 or R2) are associated with a significantly higher risk of recurrence (Evans et al., 2021)

This phase includes sulfation (adding a sulfo group), glucuronidation (adding glucuronide), glutathione conjugation (pairing), acetylation (adding an acetyl group), amino acid conjugation, and methylation

This ligand-receptor binding propagates the signal transduction in melanocytes via adenylcyclase, protein kinase A (PKA), and cyclic AMP response element binding protein (CREB) to ultimately upregulate MiTF expression

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D'Aquila T, Hung YH, Carreiro A, Buhman KK

Effect of oxidative stress on male reproduction