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Current evidence for the central role of GSH in thiol signalling suggests that the cellular redox environment is governed by the enzymatically-controlled reactions that facilitate the turnover of GSH rather than by the thermodynamic control of the GSH/GSSG couple [10]

[Abstract]May-Jun 2020;25(3):1631-1635

This phenomenon was first described by Lemasters group [37] when APAP-induced MPTP opening and necrotic cell death in primary isolated hepatocytes was attenuated by MPTP inhibitors at early time points but not late time points where caspase activation was detected

Molecular and Cellular Endocrinology, 464, 6574

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Havelund JF, Heegaard NHH, Faergeman NJK, Gramsbergen JB (2017) Biomarker research in Parkinsons disease using metabolite profiling