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Clair , nephrologist, in a Cleveland Clinic interview [Cleveland Clinic]

In the case of BBB dysfunction, neuroglial reactivity is induced by an influx of albumin, fibrinogen, among other circulating solutes, as well as blood leukocytes and their inflammatory mediators, but possibly also blood antigens, including microbial proteins that may contain pathogen-associated molecular patterns (PAMP) (Frank et al., 2021

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