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Description
10.1128/MCB.00587-15 157 WolffeA
4a and 6a and Supplementary Fig
By competing with acetylated histones for binding to BET proteins, BET inhibitors reduce oncogene expression, thereby inhibiting tumor cell proliferation and promoting apoptosis (Wang et al., 2021), observed that BEi JQ1 and I-BET 151 (I-BET) activated the JNK/ATF2 pathway in MDA-MB-231 breast cancer cells
(217) found that the iron chelator deferoxamine can inhibit pathways such as TGF-1/Smad3, inflammatory response, and oxidative stress, thereby alleviating renal fibrosis in CKD rats
Phase 3 trials currently underway will provide data on efficacy beyond one year
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