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Under physiological conditions, redox homeostasis is maintained by coordinated endogenous antioxidant systems, including the Nrf2-Keap1 signaling pathway, the glutathione (GSH) system, superoxide dismutases (SOD1 in the cytosol and SOD2 in mitochondria), catalase, glutathione peroxidases (GPXs), and the thioredoxin/peroxiredoxin network (34)

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