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, Long-term Safety and Efficacy of Achieving Very Low Levels of Low-Density Lipoprotein Cholesterol : A Prespecified Analysis of the IMPROVE-IT Trial, JAMA Cardiol

doi: 10.1126/science.289.5484.1550

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Different non-invasive techniques are discussed as follows: Drug modification for enhancing its lipid solubility As passive diffusion is the fundamental mechanism for the delivery of lipid molecules across the BBB, lipid solubility is a key factor

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