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The primary efficacy outcome in both the trials was to evaluate the pre- and post-treatment melanin indices

sustained benefits in chronic cases

However, recommendations for all four formulations may change in the future, as more specific clinical trials are conducted that examine the therapeutic benefits of one BTX treatment versus another

The changes in the glycan of placental villous, caused by excessive ROS, can lead to the decreased level of Gal-9, a type of galectins most expressed at the maternal fetal interface, whose increased levels indicate that the placental cells are susceptible to apoptosis (93)

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doi: 10.1016/s0161-6420(01)00843-0