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Neurological symptoms associated with B12 deficiencysuch as paraesthesia, ataxia, or cognitive impairmentrequire urgent treatment with more frequent injections (1mg on alternate days initially) to prevent irreversible nerve damage

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Pain reduction and mobility improvements often appear within the first week when quality products are used

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doi:10.1152/japplphysiol.00945.2010 Peenik M, Stareini M, Piri P, et al

In older adults with mild cognitive impairment, 16 weeks of 3 g/day supplementation produced measurable cognitive improvements, though benefits did not persist after discontinuation