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doi: 10.1097/AOG.0000000000000958

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A study showed that Se supplement could stimulate transcriptional adaptive program of cells to synthesize more antioxidant selenoproteins, including GPX4 and thioredoxin reductase 1 (TXNRD1), to block ferroptosis ( NADPH can also modulate ferroptosis by indirectly affecting the activity of GPX4, due to that it is a vital reductant in the process of GSH production

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[DOI] [PubMed] [Google Scholar] 236.Lawson JA, Rokach J, FitzGerald GA

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In recent decades there has been a shift in the proportions of PUFAs consumed in developed countries, including a marked reduction in omega-3s, which is posited as contributing to the pathogenesis of many diseases [80]

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250 Posttranslationally, HDAC2 deacetylates STX17, facilitating autophagosomelysosome fusion

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White adipose tissue (WAT) controls lipolysis through Adipose Triglyceride Lipase (ATGL) and hormone-sensitive lipase (HSL) enzymes (19), while brown adipose tissue (BAT) expresses UCP1 for thermogenesis (20)

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