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Meta-analysis pharmacologic treatment of obesity

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Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaenovi I, Lastra RR, Curtis M, Yamada SD, Perets R, Mcgregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E (2019) Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

Although the exact mechanism for this weight-reducing effect is unknown, the proposed mechanism includes alterated perception of taste due to carbonic anhydrase activity and modulation of dopamine and serotonin levels in the brain [241, 244, 245].Empatic has shown promising results in phase 2 clinical trials [241] (Table 2 )

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