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Similarly, it seems that the presence of only one relevant study can not firmly explain the excellent effect of LC, and larger and higher-quality studies are still needed

Mechanistically, permeation enhancement is typically achieved through transient modulation of epithelial tight junctions to increase paracellular transport, alteration of membrane organisation to facilitate transcellular diffusion, and may also influence local mucus-drug interactions or enzymatic stability depending on excipient chemistry and exposure profile (Maher et al., 2019)

Biochemistry 13 , 222245 (1974)

Mediani, A., Abas, F., Tan, C

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Javitt DC, Zukin SR