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Docking solutions were ranked according to the values of fitness function (G), which was calculated using the following formula: where c is the value of the loss of rotational and translational entropy of the complex

2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Johnstone et al., 2016), the formation of such DNA adducts induces structural distortions of the DNA helix, which in turn leads to DNA damage, which activates multiple signaling pathways, one of which is the activation of the ATM-Chk2-p53 pathway (Benkafadar et al., 2017)

These approaches address the underlying goals without the documented risks of invasive procedures, providing genuine health benefits backed by research rather than anecdotal claims

[DOI] [PubMed] [Google Scholar] 27.Weitz JI, Lensing AWA, Prins MH, et al

Research in Autism Spectrum Disorders, 62, 19

[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Sudhakar S., Manohar A., Mani E