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These patients will have a difficult time absorbing B12 unless they have appropriate amounts of stomach acid and HCL
The lack of monitoring means we cannot determine from existing clinical trial data whether semaglutide causes clinically significant b12 deficiency in typical patients
Administration of etamicastat (10 mg/kg per day, n = 45 per group), added to the drinking water, also decreased systolic blood pressure in D 2 / mice but had no significant effect in D 2 +/+ littermates
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Regular monitoring and consideration of supplementation may be appropriate
