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Meanwhile, the activities of glutathione reductase (GR) and superoxide dismutase (SOD) enzymes were also enhanced after APP treatment, while the catalase (CAT) activity decreased

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Together with the kinetic model and its full numerics of the expression derived for the doseresponse relation, an approximated form of the expression clarifies the role played by the individual biochemical processes and allows us to identify four distinct regimes for the downregulation that emerge from the balance between phosphorylation, dephosphorylation, and the cellular level of -arrestin.