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As PARP proteins require NAD + to act [67, 68], it is possible that the low NAD + levels in R cells may also reflect this mechanism
GST enzymes are essential in detoxifying endogenous or exogenous toxic compounds by catalyzing the conjugation of the nucleophilic thiol group from reduced GSH to co-substrates possessing an electrophilic center
doi: 10.1074/jbc.274.18.12670
J Biochem 1996
Timing of therapies for Down syndrome: The sooner, the better
