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Glutaredoxins Glutaredoxins (Grx) are the glutathione-dependent enzymes that catalyze the inter-conversion of soluble thiols and disulfides (trans-sulfuration) and the transfer of glutathione, cysteine, homocysteine and cysteamine groups to protein cysteines and from thiolated cysteines, as part of the biological control mechanisms

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49,71,72 Hence, targeting the Chac2GSH signaling axis offers a promising strategy for precise intervention in neutrophil pathogenic activation, thereby providing a novel therapeutic avenue for mitigating periodontitis-associated systemic inflammatory responses

Current research demonstrates that AhR target genes regulate numerous key genes and mediators involved in ferroptosis, encompassing cellular antioxidant systems, oxidative/antioxidant enzymes, heme/iron metabolism and the arachidonic acid pathway
