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(1) Omega-3 PUFAs (EPA/DHA) as core antidepressant components Deep-sea fish (e.g., salmon, mackerel) contain 23 g/100 g of EPA and DHA, which target two key pathways of depression: Inhibiting microglial activation: by inhibiting the NF-B/MAPK p38 signaling pathway and activating the neuronal BDNF-PI3K/AKT pathway, the process achieves a balance in microglial M1/M2 polarization and provides neuroprotection against neuroinflammation (313)

Ohshima et al, 2022), further expanding the potential set of ferritinophagy pathways

Striatal cholinergic interneurons Drive GABA release from dopamine terminals

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Such as a diet that includes a lot of vegetables , high quality organ meats , and the occasional supplement to maximize your glutathione
10.1016/j.atherosclerosis.2009.10.012 Atherosclerosis 72 YoshihisaY.RehmanM