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After the Tween 80/Span 20 ratio was optimized, the molar ratio of IPM to the Tween 80/Span 20 mixture was varied as 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, and 9:1 to select the optimal ratio of IPM to the surfactant mixture

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doi: 10.1113/jphysiol.2005.088310, 4 Arne DietrichN.AudiffrenM

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For example, FDA considers a food adulterated in violation of the FDCA if: i) it consists in whole or in part of any filthy, putrid, or decomposed substance or is otherwise unfit for food [2]