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10.1152/physiolgenomics.00072.2023 Physiol Genom

However, due to the instability of oligonucleotides (half-life less than 1 min), chemical modifications are mandatory, such as the substitution of 2-hydroxyl of the ribose moiety in pyrimidiones by an amino group or fluorine to ameliorate the nuclease resistance to hydrolysis and the replacement of 2-hydroxyl position of purines by 2- O -methyl [19]

On the other hand, copper also contributes to the activity of monoamine oxidases (MAOs), which are involved in the oxidative deamination of mitochondrial monoaminergic neurotransmitters, such as dopamine, serotonin, tyramine, and norepinephrine [351]

Martnez Casas OY, Daz Ramrez GS, Marn Zuluaga JI, et al

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doi:10.1111/and.12062 Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Jazayeri, S., & Reza Gohari, M
