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Since SAM is essential for many cellular transmethylation reactions (e.g., epigenetic regulation) ( Regulation of Sulfur Metabolites by Zinc Starvation ZnS interactions are essential to maintain the structure of protein domains involved in proteinprotein and proteinDNA interactions, to modulate catalysis in zinc-dependent enzymes and to generate redox switches in proteins involved in regulating the mobility, transfer, redistribution and sensing of cellular zinc ( S