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46 Diminished levels of GSH are characteristic of chronic diseases, collectively the leading cause of mortality in the world

Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63

In many other cases, the toxic reaction may be unrelated to the primary therapeutic effect (Table 53.3), and may be caused by a secondary effect that is not the primary aim of the treatment given (response 2 in Fig