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doi: 10.1073/pnas.0931245100

Accumulation of 4-HNE has been detected in various types of tissue during IRI such as heart, brain and intestine

L.Pearson-SmithJ.DayB
Excellent reviews discussing extensively this problem have been published previously (e.g., [46])

Shen Y, Li D, Liang Q, Yang M, Pan Y, Li H

Li T, Zhao N, Lu J, et al