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(d) ascorbic acid and dehydroascorbic acid

Funding: This work was supported by the National Institutes of Health grant R01-DK074114 and the Agricultural Research Center, Washington State University

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Sustained high glucose levels set in motion a cascade of pathogenic processes, such as oxidative stress, inflammation, and the activation of pro-fibrotic signalling pathways, which progressively damage renal structures, leading to glomerular sclerosis, tubulointerstitial fibrosis, and ultimately to a decline in kidney function

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