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However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

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However, the six studies showed a high heterogeneity (MD 2.70, 95% CI 2.04 to 7.44

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Fish Physiol Biochem 46:125134

For readers who want primary sources, see a PubMed report on a combination study (PubMed report), a related review article (review in PMC), and a registered clinical trial listing (ClinicalTrials.gov trial)