glutathione depletion nitric oxide Frontiers Recent Advances in Glutathione Depletion-Enhanced

Structural abnormalities, bone-related problems, and advanced degenerative changes show limited response regardless of treatment duration

10.1093/jb/mvj199 78 KandasamyS.LoganathanK.MuthurajR.DuraisamyS.SeetharamanS.ThiruvengadamR.et al

However, the benefits may not outweigh the risks

Previous studies reported that determination of cellular sensitivity to ferroptosis is mainly confined to the plasma membrane (where lipid peroxidation and FSP1-mediated detoxification occur during ferroptosis), the cytosol (where the GSH-GPX4 axis resides) and the mitochondria (where the DHODH-mediated anti-ferroptotic pathway is located)

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