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Limitations: The above-mentioned studies show promise for oral therapy in preventing the generation of immune responses against therapeutic proteins

Uricases are employed in the treatment of refractory gout and are capable of achieving a rapid reduction in hyperuricemia, significant resolution of tophi, alleviation of chronic joint pain, and enhancement of overall quality of life

Regulation of mitochondrial biogenesis

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However, none of the treatments could fully restore the disc height or achieve the same MRI T2 signal intensity as the healthy disc [96]