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According to the International Diabetes Federation, by 2040 this number will increase to 642 million (Zimmet et al., 2016[120])

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Abstract While aging is typically synonymous with the lifespan of an individual, the healthspan, or the total number of years an individual remains healthy and disease-free, is not necessarily related

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Thus, therapies targeting neutrophil activation and recruitment are not completely understood, and further research is needed

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doi: 10.3389/fbioe.2023.1272811 5 CaoX.XieH.SongM.ZhaoL.LiuH.LiG.et al

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The endothelial cells, smooth muscle cells, and immune cells of the vessel wall can form a complex inflammatory network by secreting inflammatory mediators, which jointly promote the sustained increase of blood pressure (58, 59)

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This interaction between exosomes and hBMSCs highlights the potential of targeting EV-mediated signaling in GBM therapy

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